Oestrogen, brain function, and neuropsychiatric disorders

Oestrogen, brain function, and neuropsychiatric disorders.

research on the neurobiological effects of oestrogen. Also, health professionals are being asked for guidance on whether women should be prescribed oestrogen and progestogen hormone replacement therapy (HRT) not only to treat vasomotor instability and reduce bone loss, but also in various neuropsy-chiatric disorders. However, it is controversial whether oestrogen is indicated in the treatment o...

Imaging brain chemistry and function in neuropsychiatric disorders.

Over 20 years have now passed since the first posi tron emis sion to mo gra phy (PET) stud ies were pub lished. At the time, it seemed that the mys ter ies of psy chi at ric ill nesses would be re vealed in only a few years. How na ïve we were: the brain has proved to be un be lieva bly com plex. Af ter 2 dec ades of ex pen sive and dif fi cult re search, we do not have a sin gle brainimaging t...

Gut Microbiota and Neuropsychiatric Disorders

Brain-derived neurotrophic factor and neuropsychiatric disorders.

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the invo...

Brain CB2 Receptors: Implications for Neuropsychiatric Disorders

Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB₂ receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB₂ receptor in the brain is significantly lower than that of the CB₁ receptor. Conflicting findings have been reported on the neurological effects of pharmacological a...